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![]() ![]() Turn it off to see if it resolves the issue, and if it does, find a better fix in the future so you can use both at the same time properly. In a perfect world, your old 60hz secondary monitor won’t cause FPS issues on your main screen, but in reality this happens with a TON of games. It’s supposed to work without these line switches, but they can fix things occasionally. Just try them on/off to see if it helps you. Try launching the game as “maximized” by checking the box in Properties If that doesn’t resolve the issue, try adding: Try deleting ALL of them first if you have them These are the commands you can add when you right click on desktop shortcut, hit properties, and add something like “-fullscreen” to the end of the shortcut target. Make sure that there is no NVIDIA frame capĬHECK AMD/INTEL SETTINGS: I don’t use AMD/Intel IGPU but do the same thing with the comparable AMD/Intel options as the above, if there are graphics options that can be set on a per-game basisĬHECK Chrome Line Switches. ![]() Try turning G-SYNC off if you are having issues, but typically you can keep G-SYNC on without it impacting FPS Go to your NVIDIA control panel and add your client into the 3D settings. Here are some common reasons and fixes:ĬHECK KRUNKER SETTINGS: this goes without saying but make sure you have “unlimited FPS” option enabled in Krunker and also set the frame cap to 0 or 1200.ĬHECK NVIDIA SETTINGS: This should be one of the first things you do. SOLUTION: Low FPS could be due to a large number of things. It can also happen anytime your hardware changes, like a gaming monitor or GPU. This often happens after a game or client update. PROBLEM: LOW FPS WHEN USING A KRUNKER CLIENT Still doesn’t work? Uninstall Krunker or your client completely and repeat steps above. Then, you can reload Krunker to see if it fixes it. One tip is to sort by “date modified” to see which ones you’ve used recently, to narrow things down. These folders may be different for various clients. Don’t worry about deleting something incorrectly - these folders will get repopulated again automatically. Delete anything related to “Krunker” or “electron” and “v8”. Kind of like a cache, but also for storing config. These are two folders for local data storage that get populated when playing Krunker. PROBLEM: KRUNKER CLIENT BLACK SCREEN SOLUTION: DELETE ANYTHING RELATED TO KRUNKER IN “C:\Users\USERNAME\AppData\Roaming” and “C:\Users\USERNAME\AppData\Local” Hopefully this guide will save you a lot of time. That’s because these clients are made using something called Electron which helps turn a website into a desktop app. It doesn’t matter if you use the MTZ Krunker Client, the CClient, the Official Krunker Client or the IDKR Client (which is what I typically use). Are you extremely frustrated with your Krunker Client? Then you’ve come to the right place. If you use a client, chances are that you’ve encountered problems with it before. If you are a serious Krunker player, chances are you use a “client”. Hover on specific rule for more information.ISSUES WITH THE KRUNKER CLIENT? COMMON FIXES (WORKS FOR ALL TYPES OF CLIENTS) To report a user for cheating please submit an in-game report with a video link or complete the hacker report form in the Krunker Bunker discord server (#report-hackers) We currently do not accept hacker reports. "Low Quality/Effort" posts are defined as, but not limited to, extremely pixelated images, end game/Krunker Hub leaderboard images, profile showcases, spin/skin showcases (showcasing original designs are okay). ![]() *There might be some posts which are mildy NSFW and we may allow them, always make sure by consulting with Mods before posting No impersonating other users, this includes reddit and discord staff as well. This results in a permanent ban for both parties of the transaction Krunker related content such as YouTube videos are okay to post.ĭo not buy, sell, trade any Krunker item or account for a real world item (cash, giftcards, etc). Do not joke about hacking without including /s.ĭo not post your Discord, giveaway, Twitch, YouTube, clan, etc. If you are found to be hacking and/or exploiting the game in anyway, you will be permanently banned from the subreddit (and potentially in-game too). ![]() This subreddit is meant to be helpful and constructive, please be respectful of everybody, and follow general Reddiquette practices ![]() ![]() ![]() Any 36 exposure 35mm film fine-grain developed Vaporate Treated and each good negative enlarged to. ¼-page full-color ad on back page of new four-page game day program Specs: 5” x 3. Coupon for 8x10 enlargement given with each 25c order.Durable 5’x7’ “Maxmetal” sign displayed for one year.High-impact exposure on right field wall!.Two game tickets to every home game, including playoffs.Logo’d premium giveaway to first 100 fans, onsite exposure with coupon/flyer distribution, in-game PA announcements and social media mentions Now get 15 Off on purchase over 100 at Exposures.Designated official sponsor of one “Pack-the-Park” game.Full-page full-color ad in MNHS All-Sports Program, Spring edition only.Distributed at all home games and playoff games, minimum of ten (10) editions.Save BIG w/ (2) Exposure Software verified promo codes & storewide coupon codes. ¼-page full-color ad on back page of new four-page game day program Specs: 5” x 3.75” Exposure Software promo codes, coupons & deals, July 2023.Durable 5’x7’ “Maxmetal” sign displayed for two years.High-impact exposure on right field wall for two years!.Two Major Sponsorship Levels: Grand Slam and Home Run (Clever, huh?) Thousands of fans from McKinney and the northern Metroplex attend MNHS home sporting events at Bulldog Field and the adjacent football/track multi-purpose stadium, all of whom will be exposed to your signage and messages.īulldog Baseball fan attendance continues to increase every year, with ~250 expected to attend at least ten home games in 2015. Gain Valuable Exposure for Your Business: Through various efforts, our booster club raises funds that go directly to the benefit of all levels of the Bulldog Baseball program, including: Our club has historically been one of the strongest booster clubs at MNHS, and we work diligently to provide support for our players, coaches and the entire program. We have a goal to have 100% membership from our parents. If you purchase Exposure X6 now, we’ll send you Exposure X7 for free when it’s released.The MNHS Diamond Club, Inc., a 501(c)3 non-profit organization, is the baseball booster club at McKinney North. And, it’s a great time to purchase Exposure X6 if you don’t own it already. Stay tuned to our blog for more news about the release. leafy herbs or plant matter to be placed on a 5x7 rectangle Latex or non latex gloves Sunscreen and clothing suitable for long exposure in the sun. You can move this layer up and down in the layer stack to control exactly when crop and transform is applied.Įxposure X7 will be here soon. Additionally, the new visual overlay guides like the golden triangle or golden section give you new creative composition options.Įxposure X7’s new crop and transform tools create a special crop and transform layer. ![]() The redesigned interface provides a streamlined level of control for changing crop ratios, correcting perspectives, or adding film borders without covering too much of the image. Exposure X7, Snap Art, and Blow Up plug-ins for Lightroom and Photoshop. Integrated Blow Up high-quality photo enlargement. ![]() Exposure X7 non-destructive RAW photo editor. We made this video to demonstrate what that means for your workflow. A link to download the software will be emailed to you. We’ve unified the crop and transform panels to provide a more straightforward way to compose photos. One of the exciting improvements is a change to the way you crop images. It’s a great time to be an Exposure user, especially with all the great enhancements coming in Exposure X7. ![]() ![]() ![]() Abby says new dancer Sophia sounds like Mickey Mouse. Plenty of TV and movie favorites get shoutouts in this episode. Abby brings in new girls to participate in competition in Indiana, including Hadley who appeared on ‘Abby’s Ultimate Dance Competition’ and whom Abby repeatedly called “roadkill.” The Moms and their daughters choreograph their own dance to prove they don’t need Abby. Producers have spun this into a protest to get Kelly back on the team. “Dumbass, you obviously need us.” On the second episode of Dance Moms’ third season, the Moms are sitting in the parking lot, refusing to speak on camera until their contract negotiations are met. “Abby is so gleeful that we’re gone,” says Christi. You’re losing your mind back there.” (1:24:15-1:24:40 | Christi and Kelly) She crosses herself before she dances…Can you imagine the butterflies these kids had? And people wonder why they forget their stuff. Now, my eyeballs are only ever going to the right, ever. ’Christi look at Sophia!’ What? You can't tell me where to look.
![]() This is free download The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success by Richard Koch complete book soft copy. Click on below buttons to start Download The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success by Richard Koch PDF EPUB without registration. If you are still wondering how to get free PDF EPUB of book The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success by Richard Koch. Although the 80/20 principle has long influenced todays business world, author Richard Koch reveals how the principle works and shows how we can use it in a. The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success Download The 80/20 Principle shows how we can achieve much more with much less effort, time, and resources, simply by identifying and focusing our efforts on the 20 percent that really counts. PDF / EPUB File Name: The_80_20_Principle_and_92_Other_Powerful_-_Richard_Koch.pdf, The_80_20_Principle_and_92_Other_Powerful_-_Richard_Koch.epub.Richard Koch down, work less and target a limited number of very valuable. Book Genre: Buisness, Business, Nonfiction, Personal Development, Productivity, Self Help The 80-20 Principle - Free download as PDF File (.pdf), Text File (.txt) or.Full Book Name: The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success.The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success by Richard Koch – eBook Detailsīefore you start Complete The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success PDF EPUB by Richard Koch Download, you can read below technical ebook details: ![]() It was formulated by a 19th century Italian economist named Vilfredo Pareto but has. What does Charles Darwin’s theory of natural selection prove about developing a niche product line? How can Isaac Newton’s laws of motion and gravity help in a crowded marketplace? This is a must-have book for business leaders looking for clear, evidence-based reasoning that explains why some companies seem to find success everywhere they turn, while others don’t make progress. The 80/20 Rule also known as the Pareto Principle states that 80 of the output comes from 20 of the input. In this follow-up to his best-selling “The 80 20 Principle,” the power law that helped hundreds of thousands achieve more by doing less, Richard Koch puts science to work, applying ninety-two other natural laws to promote the “science of success” within the ever-changing world of business. You can read this before The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success PDF EPUB full Download at the bottom. Here is a quick description and cover image of book The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success written by Richard Koch which was published in. The 80/20 Principle PDF book is a book written by Richard Koch that explores the concept of the 80/20 principle, which states that in many situations, roughly 80 of the effects come from 20 of the causes. Brief Summary of Book: The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success by Richard Koch Download The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success by Richard Koch in PDF EPUB format complete free. Applying this principle in your career and life will help you to be less stressed and have much more success, by focusing on the big things.The 80 20 Principle and 92 Other Power Laws of Nature: The Science of Success Download by Richard Koch.The 80/20 principle – 20% of your efforts generate 80% of your results.The Secret to Success by Achieving More Youve heard about it in other audio. ![]() Let’s jump into today’s book, The 80/20 Principle: The Secret to Success by Achieving More with Less, which is the first in a series of book reviews where I discuss the following: 11 Audio Sessions (6 hours and 47 minutes). ![]() You can submit questions for the show by clicking here. I spend most of the Engineering Career TV episodes answering questions that have been submitted from engineers around the world on how to rapidly advance their careers and live the lives they want to live. kingdom congregation philosophical allies Create successful ePaper yourself Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software. In this episode, I talk about a book titled The 8 0/20 Principle: The Secret to Success by Achieving More with Less by Richard Koch. Welcome to Episode #7 of Engineering Career TV. The 80/20 Principle by Richard Koch – A Book Review ![]() ![]() ![]() “I’m not going to lose my son at the end of 2020 and lose my country and my republic in 2021,” he told CNN, less than three weeks after Tommy’s death. He found “salvation and sustenance … a pathway back to the land of the living”. Instead of succumbing to unfathomable grief over the death of his son, Raskin seized a lifeline thrown by the House speaker, Nancy Pelosi, and agreed to lead the effort to impeach Donald Trump for inciting the riot which might have derailed the peaceful transition of power. This is where the superhuman part came in. Never had he felt “so equidistant … between the increasingly unrecognizable place called life and the suddenly intimate and expanding jurisdiction called death”. Raskin suffered “a violent and comprehensive shock to the foundations”. Six days later, a vicious mob invaded Raskin’s workplace, the cradle of democracy, leaving several dead and injuring 140 police officers. On 31 December, his beautiful, brilliant, charismatic 25-year-old son, Tommy, took his own life. When 2020 began, he had no inkling that just 12 months later his country and his family would face “two impossible traumas”. Raskin served on the board of Effective Altruism and was a member of the Harvard Animal Law Society, as well as teaching this fall for General Education 1171: “Justice: Ethics in the Age of Pandemic and Racial Calculation.Jamie Raskin is a fine writer, a Democratic congressman, a constitutional scholar and a deeply loving father. Raskin graduated from Amherst College in 2017. Raskin earned a bachelor’s degree in history, served as president of the Amherst Political Union, received a Kellogg Award, and produced “a compelling thesis on the intellectual history of the animal rights movement,” according to his parents, who published a memoir for him. Raskin, both graduates of Harvard Law School, recalled a young man with “a perfect heart, a perfect soul, a sense of incredibly brave and ruthless in humor and a brilliantly brilliant mind.” In an obituary for their son earlier this month, Jamie Raskin and his wife, Sarah B. But often these considerations and observations remain academic Tommy always wanted to make sure he put his new views into practice. Jamin Ben “Jamie” Raskin ’83 (D-Md.), noted that college is a time when people think about moral philosophy and morality. In an interview with The Crimson, his father, US Rep. Raskin’s family and friends understood his desire to improve the world in the same way that Demby did. Raskin was unwaveringly enthusiastic about helping the world’s poor, they said. Raskin’s friends and family said he will be remembered as a visionary who showed an intense commitment to justice and truth, but who had an easy way of communicating with people that made them feel heard and valued. According to a family spokesman, the cause of death was suicide after a long battle with depression. Raskin, a sophomore at Harvard Law School, died on December 31 at the age of 25. Because of this, she was “impressed and taken aback by how genuine she was as a person” and not “surprised” when she discovered a few weeks later that Raskin had donated to Oxfam on behalf of every one of her students. Raskin, however, stood out because, unlike other people, he not only advocated for the creation of a more just world, but also actively advocated for it, Demby believes. “Tommy” Raskin saying, “Shouldn’t we all do everything we can to help those less fortunate than ourselves?” during a discussion about part of Harvard’s renowned “Justice” course this fall. Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary News about Tommy Raskin Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary Tommy Raskin’s Social Media Accounts instagram Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary Tommy Raskin Net Worth net worth in dollars Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary The Tommy Raskin Family Father Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary Tommy Raskin’s educational qualifications School Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary Tommy Raskin Measurements Height Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary Biography of Tommy Raskin Name He had an unwavering enthusiasm for helping the world’s poor. “Tommy” Raskin said he will be remembered as a visionary who showed an extraordinary devotion to justice and truth. Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary – Friends and family of Thomas B. Join Telegram Link for a new update Tommy Raskin Wiki, Wikipedia, cause of death, suicide, husband, obituary ![]() ![]() ![]() The tension rises in the second half of the movie when John Creasy vows to kill everyone linked with the little girl’s death, thus portraying another sphere of emotion. The movie goes through a couple of emotions.įrom portraying John Creasy as a person filled with guilt to him finally opening himself up and generating a bond of love with a little nine-year-old girl, it leaves the views dwelled with heart-warming scenes. Easily, it is a treat for all the people who love to watch action-packed movies. The movie is packed with a lot of nail-biting actions. This includes all the kidnappers as well as all the corrupt police offers. John Creasy then sets out on a killing spree to eliminate every person responsible for the little girl’s death. Instead, they claim to give Pita the same treatment that the main kidnapper’s nephew received: death. Filled with anger, the kidnappers refused to give Pita back to her parents. The leader of the kidnapper somehow holds the Ramoses responsible for the death of his nephew. However, the random drop fails and kills ‘the Voice’s nephew in the process. Pita’s parents then try to save Pita by giving the kidnappers a ransom. However, things go on in a bad place when Pita gets kidnapped in Mexico when she goes for her Piano lesson. The movie moves forward by slowly shaving a bond generating between John Creasy and Lupita Ramos. He asks him to work as a bodyguard for a nine-year-old girl called Lupita ‘Pita’ Ramos. Rayburn suggests he indulges himself in work. Dwelling over the guilt over certain actions, he reaches Mexico to meet a friend, Paul Rayburn. ![]() Marine Corps Force Reconnaissance Captain. He depicts a melancholic and alcoholic ex-CIA Special Activities Division and U.S. In the movie, Denzel Washington plays the role of John Creasy. Thus, this movie got many viewers asking the question, is Man on Fire a true story. However, after being available on Netflix, the audience got swept away by the story, the power-packed action, and the suspense it tends to create till the end. The movie did not receive very nice ratings from the critics back in the year when it was released. ![]() It features Denzel Washington and Dakota Fanning in prominent roles. This movie was released back in the year 2022 in April. The movie Man on Fire created a buzz amongst thriller and action-packed movie lovers when it became available on Netflix. What is the plot of the movie Man on Fire? If you have not, let us take you through a synopsis of the movie to build on your excitement. If you have watched the movie, you would know the impact it leaves on the audience’s minds. Is it based on one? That we would eventually figure out as we keep on reading the article. Are you wondering why? Well, that is because it kept people wondering is Man on Fire a true story. Hence, it is difficult for a person to figure out how good and seamless the plot of the movie Man on Fire was. ![]() ![]() ![]() What maybe still missing are planets without / with a different atmosphere or other gravity.Īnyway. I guess you can find almost everything you can imagine and want in the game in terms of landscapes and climate zones. While they fight in the "old" uniforms from HELLDIVERS 1, we do so in our Power Armor Suits described above. Instead of fighting behind enemy lines, we would fight alongside regular forces to support them on the battlefield in a crucial offensive. Which means that you can only order the Airdrops which are delivered by Hell(drill)pod.Īnd maybe with the help of Hell(drill)pod it is possible to choose the drop point but you still have to find your way through the cave maze to get to the pick up point. The special thing about this type of mission would be that you fight in narrow corridors and underground. What I could imagine, for example, would be a mission type where you have to go into a bug nest to recover something, kill or catch a "special bug" or or or or. ![]() And I had to experience it again and again that I had to explain the same basics over and over again to the fresh meat, who didn't know much more than from which end of the weapon the bullets come out.īesides, it would be nice if we all had more to laugh about, wouldn't it? I have now already played a bunch of games with Helldivers who had only recently completed their basic training. This would make it easier for Newbis in particular to enter the game. On the one hand you could put more of the humor / story described above and on the other hand they would serve as an extended tutorial. After all, there is always that one player who wants to go on and doesn't want to read, see or hear something story relevant.Īnyway, this leads me to the next point. Maybe this is the only kind of humor you can experience in a coop game. The humor you experience most in the game are the fanatical comments from the Helldivers and the (involuntary) slapstick humor. The only problem is that there is far too little of it in the game. This mixture of bitter satire and (hidden) social criticism is exactly my humor. And that even though I am a total reading grouch. I remember very well how much I enjoyed reading the texts in the game. Yes, you read it right! I'd like to have more satire in the game. How much of it will be left if you start directly as a highly equipped and armoured combat machine?Īnd the most important and significant question of all is of course: Can we still wear our capes then? How well can the feeling of wearing such an Armor Suit be transferred to a Top-Down Shooter? How exactly do the "arms" work? Fully automatic? And if not, how does their control work? - After all, the developers must be able to map this in a way that is accessible to both GamePad and mouse & keyboard control.Īnd doesn't a part of the "identity" of HELLDIVERS result from the fact that the Helldivers are portrayed as elitist heroes by the propaganda, but in reality they are used like cannon fodder? To feel like cannon fodder and to laugh about failure is also part of the charm of HELLDIVERS. But there are also some questions / problems. And if we could then equip these suits, including the "arms", ourselves? ![]() How about if we could bring freedom to all the peoples of the galaxy with such suits like the one in the linked video #1? And instead of just putting our alter ego a different weapon in his hand we could give him his own suit. Well that's exactly what this thread is for. There is also the question what exactly we want or expect from a HELLDIVERS 2. Like you, I am also eager to serve Super Earth with even better tools of liberation and in new ways to protect it even better from the enemies of controlled democracy and freedom.īut apart from the question if you can even top HELLDIVERS 1 or if it is so good in itself that you can't add anything essential to it anyway. Greetings to my battle-hardened veterans and comrades of the honorable Helldivers Corps. ![]() ![]() ![]() If you do nothing, you will be auto-enrolled in our premium digital monthly subscription plan and retain complete access for $69 per month.įor cost savings, you can change your plan at any time online in the “Settings & Account” section. For a full comparison of Standard and Premium Digital, click here.Ĭhange the plan you will roll onto at any time during your trial by visiting the “Settings & Account” section. Premium Digital includes access to our premier business column, Lex, as well as 15 curated newsletters covering key business themes with original, in-depth reporting. Standard Digital includes access to a wealth of global news, analysis and expert opinion. Or, if you prefer, an iCon.During your trial you will have complete digital access to FT.com with everything in both of our Standard Digital and Premium Digital packages. There will never be a replacement for Steve. “I would love to do something in the store that commemorates Steve in some way,” says Knuth, a leader in Chicago’s community of Apple experts. He and his Lapin crew, all Apple loyalists, had a rough go of it at work Thursday. Knuth isn’t sure how he’d react to any offers to buy items from his treasure trove. “There is already active collecting interest in early Apple items first-generation Apple computers have sold for tens of thousands of dollars.” So Jobs’ passing, he predicts, is unlikely to have any long-term effect on that market. “Everyone has to die eventually, and real collectors are generally not affected much one way or the other when famous people pass,” Slater says. Will prices on the original Macintosh computers now go up? Tom Slater, Heritage’s director of Americana auctions, doesn’t think so. ![]() That’s a nice chunk of change for a tech dinosaur, but keep in mind the computer sold new for about $2,000, or $4,100 in 2010 dollars. Knuth’s brother sold a 1984 Macintosh 128K for $1,300. But he does know what some items were worth before Jobs’ passing: “People already value the original 128K Mac and that has a pretty decent market value” as a collectible, he says. Knuth, who owns an ancient Apple 2E and an 1985 128K Macintosh - upgraded to a then-astonishing 1MB of computing power - hasn’t been fielding any offers for his collection just yet. Besides repairing and selling Apples, Knuth also collects them for many years a vintage spread of Apple machines graced the display window of his Evanston, Illinois store. “There were huge, huge numbers of the machines sold,” especially after Jobs returned to the company in 1997, says Roger Knuth, owner of Lapin Systems, an Apple specialty store. Meanwhile, finding old Apple computers and peripherals that have a sort of Smithsonian cache is hard because, well, Apple sold so many. Its value today? “$3 million to $4 million, or maybe more as of yesterday,” Halperin says, “if only because more art collectors now understand the guy really had taste, and was always ahead of his time.” “He was selling many of his favorite possessions at the time because he found them a distraction and wanted to hone his focus on Apple by simplifying the rest of his life,” says Halperin, who purchased it from Jobs in 1985 for $70,000. ![]() James Halperin, co-chairman of Heritage Auctions in Dallas, Texas, owns with his wife a Maxfield Parrish painting previously owned by Jobs himself, and that was reputed to be one of Jobs’ favorites. Then there are Jobs collectibles of a different sort. (In this case, it’s assumed the winning bidder truly wants the Playboy to read the article.) A Playboy magazine featuring an extensive interview with Jobs, from February 1985, was up to $71 in a mild sort of bidding frenzy. Yet as nostalgia and fondness for the high-tech guru builds over the next few weeks, that could well change. It was as though Apple groupies, already disappointed with unveiling of the iPhone 4S, decided to cocoon with their MacBooks and pine for the good old days in private - avoiding their usual impulse to spend every spare dime on All Things Apple. Bidders cast a few scattered offers in the $12 range for the hats - maybe one or two per eBay vendor - and that was it. Nor was there barely any love for newly-minted “Steve Jobs R.I.P.” baseball caps, with the old-school Apple silhouette logo utilizing a profile of Jobs. Likewise for an Apple III System PFS Report software package, looking pristine and offered for $90. No bids on an Apple III external floppy disc drive, “buy it now” priced to sell at $160. Elsewhere on eBay, the bidding activity was so silent you could hear a hard drive chug fro 50 feet away. ![]() ![]() ![]() Patients without actionable genomic alterations were previously treated, concurrently or sequentially, with platinum-based chemotherapy and a prior PD-1 or PD-L1 inhibitor. ![]() TROPION-Lung01 is a global, randomised, multicentre, open-label Phase III trial evaluating the efficacy and safety of datopotamab deruxtecan (6.0 mg/kg) versus docetaxel (75 mg/m 2) in patients with locally advanced or metastatic NSCLC, with or without actionable genomic alterations, treated with at least one prior therapy. 6 There are currently no TROP2-directed ADCs approved for the treatment of patients with lung cancer. ![]() TROP2 is a protein highly expressed in a large majority of lung cancers. 3-5 For decades, chemotherapy has been the last treatment available for patients with advanced NSCLC in the absence of other treatment options and despite limited effectiveness and known side effects. ![]() 1,2 While immunotherapy and targeted therapies have improved outcomes in the 1st-line metastatic setting, most patients eventually experience disease progression and receive chemotherapy. More than one million people worldwide are diagnosed with advanced NSCLC each year. The data will be presented at a forthcoming medical meeting and shared with health authorities. Patients without actionable genomic alterations were previously treated, concurrently or sequentially, with platinum-based chemotherapy and a PD-1 or PD-L1 inhibitor. Patients with actionable genomic alterations were previously treated with platinum-based chemotherapy and an approved targeted therapy. TROPION-Lung01 enrolled patients with and without actionable genomic alterations, such as EGFR and ALK. There are currently no TROP2-directed ADCs approved for the treatment of patients with lung cancer. 3-5 TROP2 is a protein highly expressed in a large majority of lung cancers. We plan to share these data with regulatory authorities to discuss next steps.” Ken Takeshita, MD, Global Head, Oncology R&D, Daiichi Sankyo, said: “We are encouraged by the statistically significant results of the dual primary endpoint of progression-free survival seen with datopotamab deruxtecan and look forward to the final overall survival analysis. These first Phase III trial results from the datopotamab deruxtecan clinical programme provide compelling evidence for the potential role this TROP2-directed antibody drug conjugate can play in treating patients with lung cancer.” Susan Galbraith, Executive Vice President, Oncology R&D, AstraZeneca, said: “With TROPION-Lung01, we met the dual primary endpoint of progression-free survival, challenging the entrenched standard of care in a previously treated and unselected patient population that has long deserved an alternative to chemotherapy. Some Grade 5 events were observed.ĭatopotamab deruxtecan is a specifically engineered TROP2-directed DXd antibody drug conjugate (ADC) being jointly developed by AstraZeneca and Daiichi Sankyo. All grade interstitial lung disease was generally consistent with prior clinical trials, with the majority being low grade. The safety profile of datopotamab deruxtecan was consistent with previous clinical trials with no new safety signals identified. The investigators and participants will remain blinded to the results. The trial will continue as planned to assess OS with greater maturity. Positive high-level results from the TROPION-Lung01 Phase III trial showed datopotamab deruxtecan (Dato-DXd) demonstrated a statistically significant improvement for the dual primary endpoint of progression-free survival (PFS) compared to docetaxel, the current standard of care chemotherapy, in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) treated with at least one prior therapy.įor the dual primary endpoint of overall survival (OS), the data were not mature and an early trend was observed in favour of datopotamab deruxtecan versus docetaxel that did not meet the prespecified threshold for statistical significance at this interim analysis. |
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